- Chronic Health Conditions: Diabetes, hypertension, autoimmune diseases
- Maternal Age: Advanced maternal age (typically over 35 years)
- Pregnancy-Related Complications: Preeclampsia, gestational diabetes, placental abnormalities
- Previous Pregnancy Issues: Preterm birth, miscarriage, birth defects
- Multiple Gestation: Twins, triplets, or higher-order multiples
- Genetic Factors: Family history of genetic disorders or birth defects
- Lifestyle Factors: Smoking, alcohol consumption, substance abuse
- Environmental Exposures: Toxins, pollutants, or occupational hazards